Taken under the wing of Sara, an experienced nurse at Milton General Hospital, Shanna has no idea how her life is going to drastically change. As the new girl on the block, Shanna’s first night on the floor of the hospital will be a huge turning point for her life. Under the direction of Sara, Shanna meets her first patient, Tommy, and begins her discovery of sexual conquest. Tommy, being fully restrained and gagged, is forced to endure oppressive enemas at the hands of these depraved caretakers. The two women soon realize they have more in common with one another than just work; they both have a lust for domination and rugged lesbian sex. Sara and Shanna move in together in order to spend more time together discovering new ways to please and punish each other. Alan Young is looking for a job so he can earn enough money to be able to move out of his stepmother’s house and be free of the dominance she reins over him. He sees the ad that Shanna and Sara run for a male roommate and is very excited. Of course, he is received into the hands of the girls who cannot wait to have him at their beck and call. The women turn Alan into their personal slave, to be tortured, humiliated and changed into their very own shemale, Aileen. Dr. Wycombe, one of the most feared doctors Milton General Hospital, has tormented and raped almost all the nurses who work with him, frightening them so they will not prosecute him. Little did he know what would happen when he brutally raped Shanna in a supply closet. By getting everything on tape, she was able to get her revenge on the nasty doctor. Sara and Shanna, two obviously well matched vixens, turn their love for one another into a diabolical world of degradation and carnality, that includes an orgiastic bachelorette party and a female servant Aileen, who will find an exciting and excruciating new life of perversion she never expected.